American foreign policy towards Israel during the Biden era is affected by various factors. On the one hand, the strategic and macro alliance of these two actors has continued, and events such as October 7 and confronting Iran's threats have given it more depth. On the other hand, the macro policy of the United States in the field of reducing commitments and conflicts in the Middle East and the offshore balance policy has also affected the relations between the United States and Israel and in general the relations between actors in the Middle East. The main question of this research is "How has Biden's foreign policy approach towards the Middle East and especially Israel affected Iran's national security?" The findings of the research indicate that "by adopting the offshore balancing approach in the Middle East, Biden has sought to increase the role of Israel as well as proxy groups aligned with Tehran's interests in the Middle East." This policy has provided the basis for the expansion of tension and conflict between Iran and Israel. Also, there is a connection between America's support policy towards Israel and the threat to Iran's security environment, and the alliance of Arab countries and Israel within the framework of the Abraham Pact, the October 7 incident and the spread of conflict in the Middle East region have all affected Iran's national security. In this research, a descriptive analytical method is used and the method of collecting information is a library.